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The crash occurred about 11:52 p.m. on I-295 North in the area of milepost 63.1 in Hamilton Township, according to New Jersey State Police Trooper Charles Marchan.
The Mercedes-Benz ran off the highway to the right, overturned and struck a support for a sign, Marchan said.
The driver, whose name was withheld pending notification of next of kin, was fatally injured, he said.
The crash remains under investigation.
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